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KMID : 0812020070130020123
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Korean Journal of Neurogastroenterology and Motility
2007 Volume.13 No. 2 p.123 ~ p.131
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Optimal Frequency of Sacral Electrical Stimulation to Promote Bowel Emptying in Spinal Cord Injured Rats
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Kim Yong-Sung
Joo Min-Cheol
Lee Moon-Young
Kim Ki-Hoon
Oh Jung-Teak
Kang Dong-Baek
Shin Yong-Il
Choi Suck-Chei
Park Byung-Rim
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Abstract
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Background/Aims: The sacral nerve electrical stimulation (ES) has been used to promote bowel emptying in the spinal cord injured patients. However, optimal parameter of ES to promote bowel emptying was not established yet. The aim of this study was to investigate the effectiveness of ES to promote bowel emptying at spinal injured rats and find the optimal frequency.
Methods: Thirty-one adult Sprague-Dawley female rats were used. A complete spinal cord transection was performed surgically at the T10 cord level. The electrodes for ES were implanted in the sacral spinal cord region. Intensity of stimulation was determined by the half of the movement threshold. Stimulation width was 0.3 ms. The frequencies of ES were 10 Hz, 30 Hz, and 50 Hz, for each group. ES was applied for 4 hours per day. We measured the body weight as well as the number and the weight of fecal pellet every morning.
Results: The stool output was significantly higher in the group of 30 Hz stimulation than all other groups.
Conclusions: These results suggest that electrical stimulation could be used to promote bowel emptying in spinal cord injured patients and it is important to use an optimal frequency of stimulation for best improvement of bowel symptoms. (Kor J Neurogastroenterol Motil 2007;13:123-131)
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KEYWORD
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Bowel function, Electrical stimulation, Optimal frequency, Spinal cord injury, Sacral nerve
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